Since 1998, Negrón-Muntaner has been president of her own independent film company, Polymorphous Pictures, Inc. The objective of the company is to produce Negrón-Muntaner’s work and provide a space to collaborate with other artists and organizations, particularly those developing projects for underserved audiences, including Latino, urban, female, and gay/lesbian.

Among the companies and organizations that Polymorphous Pictures has worked with are Deston Entertainment, Baby Abuelita Productions, Bacardi, Capsule Media, Citizens' Educational Foundation, ArtCenter South Florida, Miami-Dade Cultural Affairs Council, and Taller Puertorriqueño.